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Updated: Jul 7, 2026

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry

Published on: January 7, 2014

Survival prediction in glioblastoma: 10-year follow-up from the Dutch Neurosurgery Quality Registry.

Jeroen T J M van Dijck^1,2, Hilko Ardon³, Rutger K Balvers⁴

¹Department of Neurosurgery, Haaglanden Medical Centre, The Hague, The Netherlands.

Journal of Neuro-Oncology

|May 23, 2025

Summary

Glioblastoma survival remains poor despite advances. Surgical resection and adjuvant therapy improve outcomes, but age and molecular markers significantly influence prognosis. New models aid patient-centered care.

Keywords:

Glioblastoma Patient outcome Prognostic model Survival

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Last Updated: Jul 7, 2026

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry

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Published on: January 7, 2014

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Published on: July 31, 2017

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Published on: February 24, 2023

Area of Science:

Neuro-oncology
Clinical Epidemiology
Surgical Oncology

Background:

Glioblastoma is a highly aggressive primary brain tumor with poor outcomes.
Standard treatments offer limited efficacy, necessitating improved prognostic tools.

Purpose of the Study:

To evaluate survival and prognostic factors in glioblastoma patients.
To develop pragmatic prognostic models for individualized patient care.
To analyze treatment variations and outcomes in a large Dutch cohort.

Main Methods:

Prospective cohort analysis of 7621 glioblastoma patients (2012-2022).
Univariate analysis, Kaplan-Meier curves, and Cox regression for prognostic modeling.
Funnel plots assessed center performance and surgical volume impact.

Main Results:

Median survival was 10.4 months; 2-year survival was 17.8%.
Factors influencing survival included age, ASA classification, Karnofsky Performance Status, extent of resection, complications, MGMT methylation, and adjuvant therapy.
Prognostic models achieved C-indices of 0.704 (6-month) and 0.721 (2-year).

Conclusions:

Surgical resection and adjuvant therapy improve glioblastoma survival but prognosis remains poor.
Age, premorbid condition, treatment, and molecular markers are key survival determinants.
Developed prognostic models show potential for clinical decision-making after validation.