Early detection of ventricular dysfunction in LADA using novel tissue Doppler parameters: A case-control study.

Area of Science:

• Cardiology
• Endocrinology
• Medical Imaging

Background:

• Latent autoimmune diabetes mellitus (LADA) is a common, heterogeneous form of diabetes.
• Cardiovascular implications of LADA compared to type 2 diabetes mellitus (T2DM) remain unclear.
• Subclinical cardiac dysfunction may precede overt cardiovascular events in LADA.

Purpose of the Study:

• To evaluate subclinical left and right ventricular dysfunction in LADA patients.
• To utilize novel tissue Doppler imaging (TDI) parameters for assessing cardiac function.
• To investigate the relationship between LADA, cardiac function, and serological markers.

Main Methods:

• Observational case-control study with 57 LADA patients and 60 healthy controls.
• Echocardiography (ECHO) including conventional and TDI was performed.
• Myocardial performance index (MPI) and isovolumic myocardial acceleration (IVA) were used to assess ventricular function.

Main Results:

• No significant differences in conventional ECHO parameters between groups.
• Elevated left ventricular MPI and decreased IVA in both ventricles of LADA patients.
• Negative correlations found between ventricular IVA and glutamic acid decarboxylase antibodies (GADA) levels.

Conclusions:

• LADA adversely affects systolic and diastolic function in both ventricles, more so in the left.
• TDI parameters are relevant for assessing cardiac dysfunction in LADA.
• Glycemic control and autoantibody titers are associated with cardiac function in LADA.