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Related Experiment Videos

Plasma free testosterone--is an index sufficient?

M N Nanjee, M J Wheeler

    Annals of Clinical Biochemistry
    |July 1, 1985
    PubMed
    Summary

    Measuring free testosterone in women with hirsutism can be complex. Derived free testosterone and androgen index calculations provide reliable alternatives to direct measurement, simplifying clinical assessment.

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    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Clinical Chemistry

    Background:

    • Hirsutism affects many women, but elevated total plasma testosterone is only found in about 50% of cases.
    • In cases with normal total testosterone, free testosterone levels may still be elevated.
    • Direct measurement of free testosterone is labor-intensive, leading to the use of alternative methods.

    Purpose of the Study:

    • To evaluate the correlation between directly measured free testosterone and two calculated methods: derived free testosterone and the androgen index.
    • To assess the utility of these methods in hirsute women, normally menstruating women, and women on oral contraceptives.

    Main Methods:

    • Comparison of measured free testosterone concentrations with derived free testosterone and androgen index values.
    • Study population included hirsute women, normally menstruating women, and non-hirsute women on oral contraceptive therapy.

    Main Results:

    • The study found strong correlations between measured free testosterone, derived free testosterone, and the androgen index across all participant groups.
    • All three measures yielded similar results, indicating their comparable effectiveness in assessing free testosterone status.

    Conclusions:

    • Derived free testosterone and androgen index are reliable and practical alternatives for assessing free testosterone in women.
    • These calculated methods simplify the clinical evaluation of hirsutism and related endocrine disorders.

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