Microfluidic analytical devices based on deep eutectic solvent-hydrogel thin film electromembrane extraction of...

A microfluidic analytical device based on deep eutectic solvent-hydrogel thin film electromembrane extraction was presented for the determination of bisphenol A in thermal paper, mineral, and tap water samples. The microfluidic device is constructed from two polymethyl methacrylate sections, each featuring two engraved channels. These channels serve dual purposes: one as a conduit for the sample solution and the other as a compartment for the acceptor phase. A deep eutectic ionic liquid, employed as a plasticizer, was blended into an agarose polysaccharide to create a stable, conductive, and flexible membrane. This eco-friendly membrane is positioned between the device's two sections to segregate the channels. Platinum electrodes are installed at the base of these channels and connected to a power source that facilitates the electromigration of ionized analytes across the porous agarose membrane. This new configuration enables efficient and consistent extractions using minimal sample volumes. The parameters influencing the microfluidic determination of bisphenol A were meticulously optimized. Under these conditions, the calibration curve demonstrated linearity from 0.0001 to 200 mg L^-1 with a coefficient of determination (R²) exceeding 0.9974. The relative standard deviations (RSDs %) for the extraction and quantification of bisphenol A were 3.2%.