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Related Experiment Videos

Amphetamine tolerance and body weight set point: a dose-response analysis.

D L Wolgin, J J Salisbury

    Behavioral Neuroscience
    |February 1, 1985
    PubMed
    Summary

    This study found that amphetamine tolerance and anorexia in rats do not support the set point theory of body weight regulation. Increased drug sensitivity after withdrawal, not weight set point changes, explained the observed effects.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • The set point theory proposes that amphetamine-induced anorexia and tolerance are linked to a lowered body weight set point.
    • Previous research suggests amphetamines affect appetite and weight regulation.

    Purpose of the Study:

    • To evaluate the theory that amphetamine anorexia and tolerance reflect a lowered body weight set point.
    • To investigate the dose-dependency and regulatory mechanisms of amphetamine effects on feeding and body weight in rats.

    Main Methods:

    • Rats were administered varying doses of d-amphetamine with access to milk.
    • Body weight, food intake, and behavioral responses were monitored during drug administration, withdrawal, and re-administration.

    Main Results:

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    • Comparable tolerance and weight maintenance (94%-96% of control) were observed at different amphetamine doses, indicating non-dose-dependent weight regulation.
    • Increased doses led to renewed anorexia, weight loss (79%-82% of control), and stereotypy, with highly variable individual milk intake.
    • Drug withdrawal did not significantly alter intake, and re-administration of original doses caused renewed anorexia and increased stereotypy, suggesting heightened drug sensitivity.

    Conclusions:

    • The data do not support the set point theory of amphetamine tolerance.
    • Amphetamine's effects on body weight and feeding appear to be related to increased drug sensitivity rather than active regulation around a set point.