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Non coding RNA biomarkers in pemphigus disease

  • 0School of Clinical Medicine, Shandong Second Medical University, WeiFang, ShanDong 261000, China.
Clinica Chimica Acta; International Journal of Clinical Chemistry +

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May 24, 2025

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May 24, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Non-coding RNAs (ncRNAs) show promise as biomarkers for pemphigus, a serious autoimmune blistering disease. Research highlights their potential in diagnosis, prognosis, and guiding new therapies for better patient outcomes.

Area Of Science

  • Immunodermatology
  • Molecular Biology
  • Biomarker Discovery

Background

  • Pemphigus is a severe autoimmune blistering disease caused by autoantibodies targeting desmosomal cadherins, leading to skin blistering and adhesion loss.
  • Current pemphigus diagnostics rely on invasive biopsies and serology, often lacking predictive power for disease progression or treatment response.
  • There is a critical need for reliable biomarkers to improve diagnostic accuracy, monitor disease activity, and personalize treatment strategies.

Purpose Of The Study

  • To review the role of non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in pemphigus pathogenesis.
  • To evaluate the diagnostic and prognostic potential of ncRNAs in pemphigus.
  • To explore therapeutic strategies targeting ncRNA expression in pemphigus.

Main Methods

  • Literature review of studies investigating ncRNAs in pemphigus.
  • Analysis of the regulatory functions of specific miRNAs and lncRNAs in pemphigus immunopathogenesis.
  • Assessment of the clinical translation potential and challenges of ncRNA-based biomarkers and therapeutics.

Main Results

  • Dysregulated ncRNAs, such as specific miRNAs and lncRNAs, are implicated in pemphigus by influencing key immune pathways and keratinocyte adhesion.
  • ncRNAs demonstrate potential as stable, specific biomarkers for pemphigus diagnosis and monitoring disease activity.
  • Modulating ncRNA expression presents emerging therapeutic avenues for pemphigus treatment.

Conclusions

  • ncRNAs represent promising candidates for improving pemphigus diagnosis, prognosis, and treatment personalization.
  • Further research is needed to overcome challenges in clinical translation and integrate ncRNAs into patient care.
  • Future directions focus on leveraging ncRNAs for precision medicine approaches in managing pemphigus patients.

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