Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anticonvulsant therapy and cortisol elimination.

P J Evans, R F Walker, J R Peters

    British Journal of Clinical Pharmacology
    |August 1, 1985
    PubMed
    Summary

    Anticonvulsant therapy, like phenytoin, significantly reduces cortisol half-life in epileptic patients, indicating altered drug metabolism. This highlights potential impacts of epilepsy medications on the body's stress hormone regulation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluation of infectious complications in patients with myelodysplastic syndromes: a prospective cohort study from the Canadian MDS registry.

    Annals of hematology·2024
    Same author

    Operation and performance of the ATLAS Tile Calorimeter in Run 1.

    The European physical journal. C, Particles and fields·2019
    Same author

    Observation of Centrality-Dependent Acoplanarity for Muon Pairs Produced via Two-Photon Scattering in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

    Physical review letters·2018
    Same author

    Combination of the Searches for Pair-Produced Vectorlike Partners of the Third-Generation Quarks at sqrt[s]=13  TeV with the ATLAS Detector.

    Physical review letters·2018
    Same author

    Search for Resonant and Nonresonant Higgs Boson Pair Production in the bb[over ¯]τ^{+}τ^{-} Decay Channel in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

    Physical review letters·2018
    Same author

    Search for heavy particles decaying into top-quark pairs using lepton-plus-jets events in proton-proton collisions at <math> </math>   <math></math> with the ATLAS detector.

    The European physical journal. C, Particles and fields·2018

    Area of Science:

    • Pharmacology
    • Endocrinology
    • Neuroscience

    Background:

    • Epilepsy is a neurological disorder often treated with anticonvulsant medications.
    • Cortisol is a key stress hormone regulated by the hypothalamic-pituitary-adrenal (HPA) axis.
    • Anticonvulsant drugs are known to induce liver enzymes, potentially affecting hormone metabolism.

    Purpose of the Study:

    • To investigate the effect of anticonvulsant therapy on cortisol levels and metabolism in epileptic patients.
    • To compare cortisol pharmacokinetics between epileptic patients on phenytoin and healthy individuals.
    • To assess the correlation between cortisol and antipyrine metabolism in treated epileptic patients.

    Main Methods:

    • Measured morning plasma and salivary cortisol concentrations in epileptic patients on phenytoin and healthy controls.

    Related Experiment Videos

  • Administered dexamethasone to determine the half-life of cortisol in plasma and saliva for both groups.
  • Measured antipyrine half-life and clearance rate in treated epileptic patients and controls.

    • Main Results:

    • No significant difference in baseline morning cortisol levels between epileptic patients and healthy controls.
    • Significantly reduced plasma and salivary cortisol half-lives in anticonvulsant-treated epileptic patients compared to controls.
    • Significant correlation between cortisol and antipyrine half-lives in patients, with reduced antipyrine half-life and increased clearance in treated epileptics, suggesting enzyme induction.

    Conclusions:

    • Anticonvulsant therapy, specifically phenytoin, accelerates cortisol metabolism in epileptic patients.
    • Drug-induced microsomal enzyme activity likely contributes to the altered cortisol and antipyrine pharmacokinetics.
    • These findings suggest that anticonvulsants can impact the HPA axis regulation and drug metabolism in epilepsy.