Recent advances in the synthesis of Glycoconjugated heterocycles: A promising strategy for accessing bioactive...

Glycoconjugation of biologically relevant heterocycles and natural products to create glycohybrids, combining the unique features of both structures, has emerged as a promising approach for the creation of carbohydrate-based therapeutics. This review presents a comprehensive overview of the glyco-heterocycles synthesized primarily over the past decade, offering in-depth insights into the synthetic methods employed. Additionally, the review delves into the biological activities exhibited by these molecules, with particular emphasis on the structural elements that influence their therapeutic potential. It covers the molecular hybridization of biologically privileged heterocycles-including thiadiazole, oxadiazole, pyrazole, imidazole, thiazolidine, pyridine, pyrimidine, indole, benzimidazole, benzothiazole, coumarin, quinoline, etc. with carbohydrates and explores their biological activity. By integrating insights into both synthetic strategies and bioactivity, this work aims to enhance the understanding of glyco-heterocycles as a versatile class of compounds for medicinal chemistry and drug development.