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The decrease of GluN2B and its phosphorylation at Tyr-1336 in extrasynaptic subunits is associated with

Haidong Hou1, Jing Yang2, Gang Fu3

  • 1Department of Neurosurgery, Dongguan Qingxi Hospital, Dongguan, PR China.

Brain Research Bulletin
|May 25, 2025
PubMed
Summary

Hypoxic preconditioning (HPC) reduces levels of the N-methyl-d-aspartate (NMDA) receptor subunit 2 B (GluN2B) and its phosphorylation, offering neuroprotection against brain injury. These changes, particularly in synaptic and extrasynaptic components, are key to HPC

Keywords:
GluN2BHypoxic preconditioningNeuroprotectionSynapse

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