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Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

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Disruption in the human microbiome causing behavioural changes in bipolar disorder.

Subramani Srinivasan¹

¹Department of Biochemistry, Government Arts College for Women, Krishnagiri, Tamil Nadu, India; Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.

International Review of Neurobiology

|May 25, 2025

Summary

The human microbiome, particularly gut bacteria, influences brain health via the gut-brain axis. Disruptions may contribute to Bipolar Disorder (BD) by affecting mood and cognition.

Keywords:

Bipolar disorder Brain Dysbiosis Gut microbiome Gut-brain axis

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Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

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Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Area of Science:

Neuroscience
Microbiology
Psychiatry

Background:

The human microbiome plays a crucial role in brain health and disease.
The gut-brain axis facilitates bidirectional communication between the gut and the central nervous system.
Alterations in gut microbiota composition are linked to various health conditions.

Purpose of the Study:

To explore the relationship between the human microbiome and Bipolar Disorder (BD).
To understand the microbiome's impact on mood regulation and cognitive function in BD.
To investigate potential mechanisms linking microbiome disruption to BD behavioral changes.

Main Methods:

Literature review of current research on the microbiome and mental health.
Analysis of the gut-brain axis in the context of psychiatric disorders.
Exploration of factors influencing gut microbiota, such as diet and stress.

Main Results:

The gut microbiota is increasingly recognized for its influence on neurological and psychiatric conditions.
Disruptions in the gut microbiota may affect the gut-brain axis, potentially triggering or worsening BD symptoms.
Specific microbial imbalances could be associated with mood dysregulation and cognitive deficits in BD.

Conclusions:

The microbiome is a significant factor in understanding Bipolar Disorder.
Further research is needed to elucidate the complex interplay between the microbiome and BD.
Findings may inform the development of novel therapeutic strategies targeting the microbiome for BD treatment.