Related Experiment Video
Updated: Jun 26, 2026
07:49
Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
Published on: June 2, 2022
Microbiome-based dietary supplements for better development and healthy brain.
Riddhi Upadhyay1, Sugumar Mani2, Murugan Sevanan1
1Division of Biotechnology, Karunya Institute of Technology and Sciences (Deemed University), Coimbatore, Tamil Nadu, India.
International Review of Neurobiology
|May 25, 2025
Summary
Dietary supplements targeting the gut microbiome can improve brain health and cognitive function via the gut-brain axis. Personalized strategies using AI show promise for neuroprotection, but require further validation.
Area of Science:
- Neuroscience and Microbiology
- Gut-Brain Axis Research
Background:
- The gut microbiome significantly impacts neurological functions through the gut-brain axis.
- Microbial imbalances (dysbiosis) are associated with neurological conditions like Alzheimer's, Parkinson's, and autism spectrum disorders.
Purpose of the Study:
- To explore dietary interventions (probiotics, prebiotics, postbiotics) for microbiome modulation.
- To examine the role of AI and machine learning in personalized microbiome-based strategies for brain health.
- To discuss ethical considerations and future directions in microbiome research for neuroprotection.
Main Methods:
- Review of current literature on microbiome-targeted dietary interventions.
- Exploration of AI and machine learning applications in analyzing gut microbiome data.
- Discussion of ethical challenges and regulatory needs for microbiome therapies.
Main Results:
- Dietary interventions like probiotics, prebiotics, and postbiotics can influence the gut microbiome.
- AI and machine learning enable personalized supplementation strategies based on individual gut profiles.
- Big data analytics and predictive modeling advance precision-targeted interventions for cognitive well-being.
Conclusions:
- Microbiome-based therapies offer significant potential for enhancing cognitive function and neuroprotection.
- Personalized approaches leveraging AI are key to optimizing brain health through microbiome modulation.
- Further clinical validation and regulatory frameworks are essential for the widespread adoption of these therapies.
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