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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

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Liposarcoma: Novel Approaches to Systemic Therapy and Multidisciplinary Care.

Emily Jonczak¹, Jonathan Trent¹, Christina Roland²

¹Department of Sarcoma Medical Oncology, University of Miami Sylvester Comprehensive Cancer Center, 1475 NW 12th Avenue, Miami, FL 33136, USA.

Hematology/Oncology Clinics of North America

|May 25, 2025

Summary

Retroperitoneal liposarcomas, including well-differentiated (WDLPS) and dedifferentiated (DDLPS) types, are rare bulky tumors. Complete surgical resection is the primary treatment, with chemotherapy options limited, especially for WDLPS.

Keywords:

Adriamycin Compartmental surgical resection Retroperitoneal Well differentiated/dedifferentiated liposarcoma

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Area of Science:

Oncology
Surgical Oncology
Medical Oncology

Background:

Retroperitoneal liposarcomas, encompassing well-differentiated liposarcoma (WDLPS) and dedifferentiated liposarcoma (DDLPS), are infrequent and present as large abdominal masses.
Management necessitates a multidisciplinary approach, typically within high-volume specialized centers.

Purpose of the Study:

To outline the current standard of care and treatment considerations for retroperitoneal WDLPS and DDLPS.
To highlight the role of surgery and discuss the limited efficacy of neoadjuvant therapies.

Main Methods:

Review of current treatment paradigms for retroperitoneal liposarcomas.
Emphasis on surgical resection as the primary modality.
Discussion of chemotherapy and radiation therapy roles.

Main Results:

Complete en bloc resection is the cornerstone of surgical management for curative intent.
Preoperative radiation therapy is not a standard approach.
The utility of neoadjuvant chemotherapy is under investigation, with doxorubicin-based regimens preferred for unresectable or metastatic DDLPS.
WDLPS are generally considered chemo-resistant.

Conclusions:

Surgical resection remains the primary treatment for retroperitoneal liposarcomas.
Systemic therapies have a limited role, particularly for WDLPS, and are mainly considered for unresectable or metastatic DDLPS.