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Related Experiment Video

Updated: Jan 18, 2026

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model
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Recombinant Type III Humanized Collagen Solution for Injection Promotes Skin Repair in Chinese Population: A Case

Xiaoguang Duan1, Chunmei Ding2, Jiewei Wu3

  • 1Department of Plastic Surgery, Chingho Medical Center, Shanghai, China.

Journal of Cosmetic Dermatology
|May 25, 2025
PubMed
Summary

Recombinant type III humanized collagen (RhCol-III) injections effectively reduced facial erythema and improved acne scarring in Chinese participants. The treatment also demonstrated anti-inflammatory properties in vitro, suggesting its potential for skin repair.

Keywords:
Chinese populationacne scarringfacial erythemarecombinant type III humanized collagen solution

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Area of Science:

  • Dermatology and Aesthetic Medicine
  • Biotechnology and Regenerative Medicine

Background:

  • Facial erythema and acne scarring are prevalent dermatological concerns impacting quality of life.
  • Effective treatments are sought, especially for Asian populations with specific skin characteristics.

Purpose of the Study:

  • To assess the efficacy of intradermal recombinant type III humanized collagen (RhCol-III) injections for facial erythema and acne scarring.
  • To evaluate RhCol-III's impact on skin tone and texture, and investigate its anti-inflammatory mechanisms.

Main Methods:

  • A case series of six Chinese participants (Fitzpatrick phototypes III/IV) with facial erythema and/or acne scarring received RhCol-III injections.
  • Clinical outcomes were assessed via VISIA photography and Global Aesthetic Improvement Scale (GAIS).
  • In vitro studies evaluated RhCol-III's effect on TNF-α and IL-6 secretion in LPS-induced U937 cells.

Main Results:

  • Significant reduction in facial erythema (mean decrease of 49.3%) observed post-treatment, particularly in the zygomatic area.
  • One participant showed marked improvement in acne scarring, skin tone, and texture.
  • In vitro, RhCol-III significantly decreased TNF-α (up to 47.75%) and IL-6 (up to 44.96%) levels.

Conclusions:

  • Intradermal RhCol-III injections are effective in reducing facial erythema and show potential for improving acne scarring by mitigating post-inflammatory hyperpigmentation (PIH).
  • The treatment was well-tolerated with no significant adverse effects.
  • RhCol-III solution presents a promising therapeutic option for skin repair and inflammation reduction.