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Simple Nephrectomy for Non-Functioning Kidney: An Institutional Experience with Non-Neoplastic and Incidentally
Maitrayee Roy1, Akshay Bali2, Ayushi Kediya1
1Department of Pathology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Maharishi Markandeshwar Deemed to be University, Mullana-Ambala, Haryana, India.
International Journal of Surgical Pathology
|May 26, 2025
Summary
Histopathological examination of simple nephrectomy specimens is crucial. Unsuspected kidney neoplasms were found in 4% of patients with non-functional kidneys, highlighting the importance of detailed analysis.
Area of Science:
- Nephrology
- Pathology
- Urology
Background:
- Chronic kidney diseases have diverse causes.
- Simple nephrectomy is performed for non-functional kidneys.
- Neoplasms can be incidentally discovered post-nephrectomy.
Purpose of the Study:
- To evaluate the histopathological findings of simple nephrectomies in non-functional kidneys.
- To determine the incidence of unsuspected neoplasms in these cases.
Main Methods:
- Retrospective analysis of 275 simple nephrectomies (2019-2024).
- Exclusion of cases with pre-operative tumor suspicion.
- Histopathological examination of all specimens.
Main Results:
- Chronic pyelonephritis was the most common diagnosis (79.3%).
- Neoplasms were found in 4% of cases.
- Clear cell renal cell carcinoma was the most frequent neoplasm (27.2% of neoplasms).
Conclusions:
- Detailed histopathological analysis of simple nephrectomy specimens is essential.
- Neoplastic pathologies can occur unexpectedly in non-functional kidneys.
- This evaluation has significant therapeutic implications.
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