Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.1K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.1K
Assumptions of Survival Analysis01:15

Assumptions of Survival Analysis

401
Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
401
Censoring Survival Data01:09

Censoring Survival Data

529
Survival analysis is a statistical method used to analyze time-to-event data, often employed in fields such as medicine, engineering, and social sciences. One of the key challenges in survival analysis is dealing with incomplete data, a phenomenon known as "censoring." Censoring occurs when the event of interest (such as death, relapse, or system failure) has not occurred for some individuals by the end of the study period or is otherwise unobservable, and it might have many different...
529
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

250
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
250
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

243
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
243
Expected Frequencies in Goodness-of-Fit Tests01:19

Expected Frequencies in Goodness-of-Fit Tests

7.2K
A goodness-of-fit test is conducted to determine whether the observed frequency values are statistically similar to the frequencies expected for the dataset. Suppose the expected frequencies for a dataset are equal such as when predicting the frequency of any number appearing when casting a die. In that case, the expected frequency is the ratio of the total number of observations (n)  to the number of categories (k).
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Posttraumatic stress in German volunteer lifeguards: evidence for the building block effect.

BMC public health·2026
Same author

Assessing three altruism facets by economic games and self-report: a multitrait-multimethod investigation.

Scientific reports·2026
Same author

Handling missing values when using neighborhood selection for network analysis.

Psychological methods·2026
Same author

Optimizing the Short Dark Triad Scale Using an Ant Colony Optimization Algorithm.

Assessment·2026
Same author

Time-Varying Network Models for the Temporal Dynamics of Depressive Symptomatology in Patients With Depressive Disorders: Secondary Analysis of Longitudinal Observational Data.

JMIR mental health·2024
Same author

Simulation-Based Performance Evaluation of Missing Data Handling in Network Analysis.

Multivariate behavioral research·2024

Related Experiment Video

Updated: Jan 18, 2026

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
07:11

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Published on: November 10, 2023

3.2K

Missing Data Handling via EM and Multiple Imputation in Network Analysis using Glasso and Atan Regularization.

Kai Jannik Nehler1, Martin Schultze1

  • 1Department of Psychology, Goethe University Frankfurt, Frankfurt am Main, Germany.

Multivariate Behavioral Research
|May 26, 2025
PubMed
Summary

This study compares multiple imputation and EM methods for handling missing data in psychological networks. Stacked multiple imputation is most consistent for nonconvex regularization, while two-step EM excels with convex regularization.

Keywords:
Network analysismissing valuesmultiple imputationregularizationsimulation study

More Related Videos

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
08:27

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

4.8K
Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors
06:32

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors

Published on: August 18, 2023

2.9K

Related Experiment Videos

Last Updated: Jan 18, 2026

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
07:11

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Published on: November 10, 2023

3.2K
Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
08:27

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

4.8K
Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors
06:32

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors

Published on: August 18, 2023

2.9K

Area of Science:

  • Psychological network analysis
  • Statistical methodology
  • Missing data handling

Background:

  • Current literature on missing data in psychological networks is limited to likelihood-based methods.
  • Existing approaches often focus on convex regularization with varied missing data handling implementations.
  • There is a need for standardized and comparative evaluations of different missing data handling techniques.

Purpose of the Study:

  • To implement and evaluate a missing data handling approach using stacked multiple imputation.
  • To compare stacked multiple imputation against direct and two-step EM methods.
  • To assess performance under varying network conditions and regularization types.

Main Methods:

  • Simulated cross-sectional psychological networks with varying network size, observations, and missingness.
  • Implementation of stacked multiple imputation, direct EM, and two-step EM methods.
  • Evaluation using convex (glasso) and nonconvex (atan) regularization with EBIC and BIC model selection.

Main Results:

  • Missing data handling methods showed similar performance across many simulated conditions.
  • Two-step EM with glasso and EBIC performed best overall, followed closely by stacked multiple imputation.
  • Stacked multiple imputation was most consistent for atan regularization with BIC.

Conclusions:

  • Stacked multiple imputation offers a viable and consistent alternative for missing data handling in psychological networks, particularly with nonconvex regularization.
  • The choice of missing data handling method can depend on the regularization technique employed.
  • Further research comparing imputation and EM methods in network analysis is warranted.