Related Experiment Video
Updated: Sep 20, 2025
Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
Published on: December 15, 2014
Accuracy of high b-value diffusion-weighted imaging in identifying benign and malignant breast lesions: a systematic
Jupeng Zhang1,2, Qi Wu1,2, Xiqi Zhu1,3
1Department of Radiology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Objective:
To evaluate the diagnostic accuracy of high b-value diffusion-weighted imaging (DWI) in differentiating malignant from benign breast lesions.
Methods:
A comprehensive literature search was conducted across PubMed, Embase, Cochrane Library, Scopus, and Web of Science for English-language studies on high b-value DWI in breast lesions, from inception to June 2024. Study quality was assessed, and data were extracted. Heterogeneity analysis, forest plots, Deek's funnel plots, and summary receiver operating characteristic (SROC) curves were generated using Stata 16.0 and Meta-Disc 1.4 software. Meta-regression identified sources of heterogeneity.
Results:
The meta-analysis included 12 studies with 1,747 patients and 1,861 breast lesions (1,000 malignant, 861 benign). Pooled diagnostic metrics were: sensitivity, 0.91 (95% CI: 0.87-0.94); specificity, 0.93 (95% CI: 0.87-0.96); positive likelihood ratio, 12.21 (95% CI: 6.91-21.57); negative likelihood ratio, 0.09 (95% CI: 0.06-0.14); diagnostic odds ratio, 130.75 (95% CI: 56.95-300.21); and AUC, 0.97 (95% CI: 0.95-0.98).
Conclusion:
High b-value DWI has high diagnostic accuracy in differentiating between benign and malignant breast lesions, demonstrating potential as a reliable imaging marker.
Registration:
PROSPERO (CRD42024568777).
