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Published on: May 4, 2021

Emerging role of exosomal-microRNA in obesity

Achala Theres P Moncy1,2, Samarjit Das2, Hannah R Vasanthi1

  • 1Department of Biotechnology, Pondicherry University, Puducherry, India.

Current Opinion in Physiology
|May 26, 2025
PubMed

Insights

Exosomes, tiny vesicles carrying microRNAs (miRNAs), are crucial in cell communication and obesity. These exosomal miRNAs show promise as early diagnostic biomarkers and therapeutic targets for obesity and related conditions.

Area of Science:

  • Cell biology
  • Biochemistry
  • Metabolic diseases

Background:

  • Exosomes are extracellular vesicles involved in intercellular communication.
  • Exosomal microRNAs (miRNAs) are implicated in various pathophysiological processes.
  • Obesity involves complex mechanisms, including cellular signaling pathways.

Purpose of the Study:

  • To review the role of exosomal miRNAs in obesity.
  • To highlight exosomal miRNAs as potential diagnostic biomarkers.
  • To discuss exosomal miRNAs as therapeutic targets for obesity.

Main Methods:

  • Literature review of recent studies on exosomal miRNAs and obesity.
  • Analysis of the role of exosomal cargo, specifically miRNAs, in obesity pathogenesis.
  • Evaluation of the diagnostic and therapeutic potential of exosomal miRNAs.

Main Results:

  • Exosomal miRNAs play a significant role in obesity progression.
  • These miRNAs are involved in obesity-associated pathophysiological conditions.
  • Exosomal miRNAs are identified as key players in metabolic dysregulation.

Conclusions:

  • Exosomal miRNAs are critical in understanding obesity.
  • They represent promising early diagnostic biomarkers for obesity.
  • Exosomal miRNAs offer potential therapeutic strategies for obesity management.
Keywords:
BiomarkersExosomesObesitySmall extracellular vesicles (EVs)TherapymiRNA

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