[Effect of hypolipidemic preparations on basal and stimulated adenylate cyclase activity in tumor cells]

A study was made of the action of the antidiabetic biguanide phenformin, clofibrate and the phospholipid drug Essentiale on the basal and adrenaline-stimulated activity of adenylate cyclase in Ehrlich's ascites carcinoma cells. All the drugs under study potentiated the hormone-stimulated activity of adenylate cyclase. Unlike phenformin and Essentiale, clofibrate did not exert any effect on the basal activity of adenylate cyclase. On the other hand, certain differences were revealed in changes of the lipid content of tumor cells during application of the drugs in question. Stimulation of adenylate cyclase activity by hypolipidemic drugs is regarded as a promising approach to the goal-oriented changing of hormonal sensitivity of tumor cells.