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Updated: May 23, 2026
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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Epiretinal Membranes Associated With Choroidal Melanoma.
Feng Li1,2, David M Hinkle2, Paul T Finger1,2
1Department of Ocular Tumor, Orbital Disease, and Ophthalmic Radiation Therapy, The New York Eye Cancer Center, New York, NY, USA.
Journal of Vitreoretinal Diseases
|May 26, 2025
Summary
Epiretinal membranes (ERMs) are more common in eyes with choroidal melanoma. Factors like radiation dose, radiation retinopathy, anti-VEGF injections, and retinal detachment increase ERM risk.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Epiretinal membranes (ERMs) can affect vision.
- Choroidal melanoma is a primary intraocular malignancy.
Purpose of the Study:
- To determine the prevalence of ERMs in eyes diagnosed with choroidal melanoma.
- To identify risk factors associated with ERM development in these eyes.
Main Methods:
- Retrospective case review of 373 patients with choroidal melanoma.
- Ophthalmoscopy, fundus photography, and optical coherence tomography were used for examination.
- Multivariate analysis assessed ERM association with tumor characteristics, radiation dose, and treatments.
Main Results:
- ERMs were present in 34% of treated choroidal melanoma eyes versus 12.1% of controls.
- Larger tumor size and higher foveal radiation dose correlated with ERM presence.
- Radiation retinopathy, anti-VEGF injections, and retinal detachment (RD) were significant risk factors.
Conclusions:
- Eyes with choroidal melanoma have a significantly higher prevalence of ERMs.
- Radiation dose, radiation retinopathy, anti-VEGF injections, and RD are key contributors to secondary ERM formation.
- Retinal detachment at diagnosis is the strongest predictor for secondary ERM development.
