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Relationship Between Leptin and Heart Failure: A Meta-Analysis
Xin Sun1, Caihong Xin2, Jiayi Yao1
1Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, Suzhou, CN.
Global Heart
|May 26, 2025
Summary
Leptin levels are significantly higher in individuals with heart failure (HF) compared to healthy controls. This meta-analysis clarifies the controversial association between leptin and HF, aiding potential diagnostic and therapeutic strategies.
Area of Science:
- Cardiology
- Endocrinology
- Biomarkers
Background:
- Heart failure (HF) affects over 60 million globally, presenting a significant health challenge.
- Previous research suggests a link between leptin and HF, but findings are inconsistent.
- The precise association between leptin levels and heart failure remains controversial.
Purpose of the Study:
- To systematically review and meta-analyze existing studies on leptin levels in heart failure patients.
- To clarify the controversial relationship between leptin and heart failure.
Main Methods:
- A comprehensive literature search was performed across major scientific databases (Web of Science, Wiley, Embase, PubMed).
- Studies were identified using keywords 'leptin' combined with 'heart failure' and 'HF'.
- Meta-analysis was conducted, reporting standardized mean differences (SMD) and 95% confidence intervals (CI).
Main Results:
- Eighteen studies involving 1149 HF patients and 622 healthy controls were included.
- Leptin levels were found to be significantly elevated in patients with heart failure compared to healthy individuals (SMD, 0.54; 95% CI [0.15, 0.93]).
Conclusions:
- This systematic review is the first to comprehensively evaluate the relationship between leptin and heart failure.
- The findings indicate a significant association between higher leptin levels and heart failure.
- Understanding leptin's role in HF could advance diagnostic and treatment approaches.
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