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Updated: Sep 20, 2025

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
Published on: August 24, 2019
Inspiratory Muscle Training on Exercise Capacity, Dyspnoea and Health Status in Pulmonary Hypertension: A Randomised
Fabrício Farias da Fontoura1,2,3, Gabriela Roncato4, Gisela Martina Bohns Meyer2
1Programa de Pós-graduação em Ciências Pneumologicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Background And Objective:
To evaluate the effects of a high-intensity inspiratory muscle training on respiratory muscle strength, exercise capacity, dyspnoea, and health-related quality of life (HRQL) in patients with pulmonary hypertension (PH).
Methods:
Single-blinded, randomised controlled trial 35 women with clinically stable PH (subgroups 1 and 4), functional class II and III, were randomly assigned to a high-intensity inspiratory muscle training (IMT) or sham training. Daily 8-week IMT protocol with 50% (IMT-50%) of maximal inspiratory muscle pressure (PImax) or sham training with a fixed load of 3 cmH2O (IMT-S). Daily training time consisted of 2 cycles of 30 dynamic inspiratory efforts twice daily, 7 days/week, for 8 weeks using an inspiratory threshold-loading device.
Results:
There were significantly greater improvements in the intervention group (17 patients) compared to sham (14 patients) on PImax [Δpost-pre = 56.4 cmH2O (95% CI 63.5 to 49.3) versus IMT-S 25.2 cmH2O (95% CI 33.1 to 17.4), p < 0.001]. The intervention group improved their 6MWT [Δpost-pre, IMT 50% = 33.5 m (95% CI 15.9 to 51.2) vs. IMT-S -1.1 m (95% CI -26.7 to 24.4), p < 0.001]. Dyspnoea perception at the end of the 6-min walk test (6MWT) and mMRC significantly improved in the IMT-50% group: Dyspnoea [Δpost-pre = -1.1 (95% CI -1.5 to -0.7) vs. IMT-S -0.2 (95% CI -1.3 to 0.9), p < 0.001] and mMRC [Δpost-pre = -0.6 (95% CI -0.8 to 0.3) vs. IMT-S 0 (95% CI -0.2 to 0.2), p < 0.001].
Conclusions:
A high-intensity protocol of IMT improves respiratory muscle strength, exercise capacity, and dyspnoea in symptomatic patients with PH.
Trial Registration:
The trial was recorded on the Trials registry RBR-33gm3k (https://ensaiosclinicos.gov.br/rg/RBR-33gm3k).
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