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Nature-Inspired Macromolecular Biocomposites Based on Decellularized Extracellular Matrix
Yihan Lin1, Yuting Lin1, Haohua Hu1
1Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, P. R. China.
Macromolecular Rapid Communications
|May 26, 2025
Summary
Decellularized extracellular matrix (dECM) composites enhance biological functions for biomedical applications. This review summarizes preparation techniques and properties of dECM composites for diverse needs.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Extracellular matrix (ECM) provides structural support and regulates cellular activities.
- Decellularized ECM (dECM) shows promise in biomedicine but has limitations.
- dECM-based composite biomaterials enhance biological functions and clinical applicability.
Purpose of the Study:
- To summarize preparation techniques for dECM-based composite biomaterials.
- To classify different types of dECM composites and discuss their properties.
- To highlight the suitability of these composites for specific biomedical applications.
Main Methods:
- Review of literature on dECM-based composite biomaterials.
- Summary of preparation techniques including physical crosslinking, chemical modification, 3D printing, and electrospinning.
- Classification and discussion of biological and material properties of various dECM composites.
Main Results:
- Various preparation techniques can create dECM composites with tailored properties.
- dECM composites offer enhanced biological functions compared to simple dECM.
- Different composite types exhibit distinct properties suitable for specific biomedical applications.
Conclusions:
- dECM-based composite biomaterials represent a significant advancement in regenerative medicine.
- Tailored preparation techniques are crucial for optimizing dECM composites for clinical translation.
- This review provides a comprehensive reference for developing and applying dECM composites.
