Related Experiment Video
Updated: Jun 20, 2026
18:30
Rat Mesentery Angiogenesis Assay
Published on: June 18, 2011
14.0K
Alternate Dosing Regimens for Vismodegib: A Literature Review
Kevin Yang1, Hoang Ho-Pham2, Collin Pieper2
1Department of Dermatology, University of Alabama at Birmingham, 510 20th St. S, FOT 858, 35233, Birmingham, AL, USA. yangkevin11@yahoo.com.
Current Treatment Options in Oncology
|May 26, 2025
Summary
Vismodegib treatment for basal cell carcinoma can cause side effects. Adjusting the dosing schedule, like using intermittent dosing or drug holidays, may improve patient tolerability and treatment adherence.
Area of Science:
- Oncology
- Dermatology
Background:
- Vismodegib is a hedgehog inhibitor for basal cell carcinoma (BCC) and basal cell nevus syndrome.
- Treatment often leads to side effects (fatigue, cramps, hair loss, taste disturbance) impacting patient compliance.
Purpose of the Study:
- To explore strategies for improving vismodegib tolerability.
- To evaluate the suitability of non-daily dosing and drug holidays for managing side effects.
Main Methods:
- Review of current clinical practices and literature on vismodegib dosing modifications.
- Analysis of potential benefits of intermittent dosing versus drug holidays based on patient condition.
Main Results:
- Non-daily dosing and drug holidays are strategies to mitigate vismodegib-induced side effects.
- Intermittent dosing may suit locally advanced BCC, while drug holidays might be better for basal cell nevus syndrome.
Conclusions:
- Dosing adjustments can enhance vismodegib tolerability.
- The optimal dosing strategy should be individualized, considering patient preference and specific condition (BCC vs. basal cell nevus syndrome).
More Related Videos
Related Concept Videos
01:15Drug Dosage Regimen: Overview
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
01:01Dosage Regimen: Fixed Dose
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
01:28Dosage Regimens: Designs and Approaches
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
01:01Dosage Regimens: Partial Pharmacokinetic Parameters
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
01:25Dosage Regimen: Multiple Oral Dosage
Understanding how a drug's concentration fluctuates within the body over time is crucial in pharmacokinetics, particularly with multiple oral doses. A graphical representation of multiple oral dosages provides insight into these dynamics. Typical accumulation curves of a drug's concentration in the body reveal a sawtooth pattern, indicating periodic peaks and troughs correlating with each dose administration and the drug's subsequent elimination.The plasma concentration at any time during an...
01:24Dosage Regimen: Individualization
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...