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Related Experiment Video

Updated: May 12, 2026

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

3D multi-phase balanced non-steady-state free precession acquisition for multi-parameter mapping.

Riwaj Byanju¹, Gyula Kotek¹, Mika W Vogel²

¹Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.

Magma (New York, N.Y.)

|May 26, 2025

Summary

This summary is machine-generated.

This study introduces a 3D multi-parametric mapping sequence (MP-b-nSSFP) for faster MRI scans. While accurate in phantoms, in vivo T1 mapping showed underestimation compared to reference methods.

Keywords:

Extended readout SSFP Subspace-constrained Transient imaging qMRI

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Area of Science:

Magnetic Resonance Imaging (MRI)
Biomedical Engineering
Medical Physics

Background:

Multi-parametric mapping provides comprehensive tissue characterization.
Fast and accurate MRI techniques are crucial for clinical applications.

Purpose of the Study:

To present and evaluate a novel 3D multi-parametric balanced steady-state free precession (MP-b-nSSFP) sequence.
To assess the feasibility of achieving clinically acceptable scan times for multi-parametric mapping.

Main Methods:

Evaluation of 3D MP-b-nSSFP sequence parameters: RF pulse type, readout duration, undersampling, and acceleration factor.
Utilized subspace-constrained reconstruction and extended spiral readouts for accelerated acquisition.
Compared repeatability and accuracy of T1 and T2 maps against a reference technique in phantoms and volunteers.

Main Results:

Non-selective RF pulses demonstrated lower bias compared to selective pulses.
Phantom T1 and T2 maps agreed well with nominal and reference values.
In vivo T1 values were underestimated relative to the reference scan.
Acquisition of high-resolution maps (1x1x3 mm^3) was achieved in 11 minutes.

Conclusions:

The 3D MP-b-nSSFP sequence enables multi-parametric mapping within clinically relevant scan times.
Phantom results show good agreement with reference methods, validating the sequence's potential.
Further investigation is needed to address the underestimation of in vivo T1 values.