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Related Concept Videos

Immunodeficiency Diseases01:25

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Related Experiment Video

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Structuring and standardizing outcome measures using the ICF framework in adults with primary immunodeficiency.

Ecran Cinkavuk1, Ugur Hacı Muşabak2, Sait Yesillik3

  • 1Department of Cardiorespiratory Physiotherapy and Rehabilitation, Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.

Disability and Rehabilitation
|May 26, 2025
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Summary

Adults with primary immunodeficiency (PID) experience significant impairments in exercise capacity, sleep, and daily activities. Utilizing the International Classification of Functioning (ICF) framework aids rehabilitation planning for improved functional capacity in PID patients.

Keywords:
ICFPrimary immunodeficiencyexercise capacityphysical activityquality of life

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Area of Science:

  • Immunology
  • Rehabilitation Medicine
  • Public Health

Background:

  • Primary immunodeficiency (PID) encompasses a diverse group of genetic disorders affecting immune system function.
  • Understanding the functional impact of PID in adults is crucial for effective management.

Purpose of the Study:

  • To evaluate adults with primary immunodeficiency (PID) using the International Classification of Functioning, Disability, and Health (ICF) framework.
  • To identify functional impairments and barriers experienced by adults with PID.

Main Methods:

  • A cohort of 20 adults with PID and 20 healthy controls were assessed using ICF criteria.
  • Evaluations included exercise capacity, hand-grip strength, sleep, fatigue, body composition, posture, muscle mass, quality of life, daily activities, and physical activity.
  • Barriers related to societal attitudes and health, employment, and transportation services were also assessed.

Main Results:

  • Adults with PID showed significant deficits in exercise capacity, hand-grip strength, sleep function, and body composition compared to controls.
  • Fatigue severity was notably higher in the PID group.
  • Quality of life and daily living activities were significantly poorer in individuals with PID.

Conclusions:

  • The ICF framework provides a comprehensive approach to assessing functional capacity in adults with PID.
  • ICF-based evaluations can guide goal-oriented rehabilitation strategies.
  • This approach can lead to improved functional outcomes and quality of life for adult PID patients.