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Bioactive protein/polysaccharide hydrogel functionalized bone implants surface for enhanced osteogenesis.

Hongyun Ma1, Xiaochen Su2, Jingqi Liang3

  • 1Foot and Ankle Surgery Department, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, China; Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710000, China.

International Journal of Biological Macromolecules
|May 26, 2025
PubMed
Summary

Bioactive hydrogel coatings enhance bone implant integration and repair by mimicking natural tissues. This review covers polysaccharide and protein hydrogels, biomechanical mechanisms, and future directions for orthopedic treatments.

Keywords:
Bioactive materialsBiomechanical regulationBone tissue engineeringBone tissue repairClinical translationHydrogel modificationOsteogenic mechanism

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Area of Science:

  • Biomaterials Science
  • Orthopedic Engineering
  • Regenerative Medicine

Background:

  • Conventional bone implants face challenges in bone repair and osteointegration.
  • Bioactive implants with biomimetic surfaces show promise for improved bone integration.
  • Biomedical hydrogel coatings offer tunable biomechanics and bioactivity for implant modification.

Purpose of the Study:

  • To review recent advances in hydrogel modification for bone implants.
  • To explore biomechanical mechanisms of bone formation with hydrogel-modified implants.
  • To identify challenges and future directions in hydrogel-based bone implant development.

Main Methods:

  • Review of polysaccharide hydrogels (chitosan, alginate, hyaluronic acid).
  • Review of protein hydrogels (gelatin, collagen).
  • Analysis of biomechanical mechanisms and clinical perspectives.

Main Results:

  • Hydrogel coatings facilitate "soft-hard synergy" for bone repair.
  • Polysaccharide and protein hydrogels show potential for bone implant enhancement.
  • Understanding biomechanical mechanisms is crucial for optimizing bone formation.

Conclusions:

  • Hydrogel modification is a promising strategy for improving bone implant performance.
  • Further research is needed to address challenges and advance clinical applications.
  • Integrating engineering, biology, and clinical insights is key for developing functional bone implants.