Astraeusols A-E: lanostane-type triterpenes from the wild edible mushroom Astraeus asiaticus

Five previously undescribed lanostane-type triterpenes, astraeusols A-E (1-5), along with astraeusin M (6), astrasiate (7), astraeusin A (8), artabotryol A (9), artabotryol B (10), artabotryol C2 (11), cerevisterol (12), 6-epi-cerevisterol (13), and linoleic acid (14), were isolated from the fruiting bodies of the Thai wild edible mushroom Astraeus asiaticus. Astraeusols D (4) and E (5) were identified as lanostane triterpenes linked to phenylethylamine through amide linkages for the first time from a natural source. The configuration at C-25 of the original structure of artabotryol C2 (11) was revised from 25R to 25S. The structural determinations were based on physical data and spectroscopic evidence, including 1D and 2D NMR analyses.