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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Related Experiment Video

Updated: Jul 10, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
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Recommendations of perioperative systemic therapies considering age or comorbidities in the National Comprehensive

Sruthi Ranganathan1, Myung Sun Kim2, Timothee Olivier3

  • 1Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

Journal of Cancer Policy
|May 26, 2025
PubMed
Summary

National Comprehensive Cancer Network (NCCN) guidelines lack specific recommendations for perioperative cancer therapy considering patient age and comorbidities. Many existing guidelines lack strong evidence, highlighting a need for more personalized cancer treatment guidance.

Keywords:
NCCNPerioperative therapy

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Area of Science:

  • Oncology
  • Clinical Guidelines
  • Evidence-Based Medicine

Background:

  • Perioperative therapy aims to reduce cancer recurrence and improve long-term outcomes.
  • Patient age and comorbidities significantly impact perioperative therapy effectiveness and safety.
  • National guidelines, like NCCN, should address these patient-specific factors.

Purpose of the Study:

  • To evaluate NCCN guidelines for age and comorbidity considerations in perioperative cancer therapy.
  • To assess the evidence supporting existing NCCN recommendations for specific patient subgroups.

Main Methods:

  • Cross-sectional study of NCCN recommendations.
  • Analysis of guidelines for 10 major cancer types.
  • Evaluation of age/comorbidity-specific guidance and supporting literature.

Main Results:

  • Only 2 of 10 cancer types had age-specific perioperative guidelines.
  • 4 of 10 cancer types had comorbidity-specific perioperative guidelines.
  • Half of guidelines offered vague advice on age and comorbidities, often lacking strong RCT support.

Conclusions:

  • NCCN guidelines show a significant lack of age and comorbidity-specific recommendations for perioperative cancer therapy.
  • Existing recommendations are frequently not supported by robust evidence.
  • Development of comprehensive guidelines accounting for patient-intrinsic factors is crucial.