[Occurrence risk of extrahepatic liver tumor with hepatitis B virus infection]

Hepatitis B virus (HBV) infection is a global public health problem, which mainly causes a series of liver diseases such as hepatitis, liver cirrhosis, and hepatocellular carcinoma. However, recent years' studies have shown that the occurrence of multiple extrahepatic malignancies may also be associated with HBV infection. For example, studies have found that patients with HBV infection have a significantly higher risk of developing digestive system tumors such as gastric cancer, colorectal cancer, and pancreatic cancer, as well as an increased risk of other systemic malignancies such as lymphoma, leukemia, and oral cancer. Although the liver is the primary target organ of HBV, the presence of the virus in non-hepatic tissues suggests that it may play an impact in the development of other extrahepatic tumors. The findings of these associations have important implications for public health policies and cancer prevention strategies, emphasizing the need for multisystem tumor screening in patients with HBV infection.