Penile cancer treatment and sexuality: a narrative review

Penile squamous cell carcinoma is a rare malignancy that poses a significant concern to those affected due to its aggressive nature and profound impact on patients' quality of life. This review examines the evidence on the impact of penile cancer and its various treatments on the sexual health of patients. Men's post-surgical sexual functioning has mainly been assessed with the International Index of Erectile Functioning. Some studies asked men to report retrospectively on pre-surgical sexual functioning or compared surgical techniques with non-randomized samples. Studies on patient's perspectives on sexual sensations and appearance are emerging,  however reliable assessments of sexual wellbeing are missing. Penile cancer significantly impacts patients' sexual activity, sexual function, sexual sensations, cosmesis and sexual wellbeing. Considerable proportions of patients resume sexual activity following treatments, including organ-sparing procedures, partial or total penectomy, and adjuvant therapies. While organ-sparing surgeries can largely preserve sexual functioning, more invasive treatments like partial or total penectomy result in greater declines, with the impact on sexual wellbeing remaining underexplored. Rigorous prospective studies assessing valid and reliable patient reported outcome measures for sexual wellbeing besides sexual functioning are needed in order to fully understand and address the impact of penile cancer treatment on sexual health.