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Effect of probiotics on prognosis in patients with hepatectomy: a systematic review and meta-analysis of randomized controlled trial

  • 0Department of Hepatobiliary Surgery, Dazhou Integrated TCM & Western Medicine Hospital, Dazhou, Sichuan, 635000, China. jiangqinghucqmu@163.com.
Bmc Pharmacology & Toxicology +

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May 26, 2025

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May 26, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Perioperative probiotics significantly reduce infection risk and hospital stays in hepatectomy patients. However, they do not improve liver function or reduce inflammation post-surgery.

Area Of Science

  • Gastroenterology and Hepatology
  • Surgical Oncology
  • Microbiome Research

Background

  • Hepatectomy, a major liver surgery, carries risks of postoperative complications.
  • Optimizing patient recovery and reducing infection rates are critical in hepatectomy care.
  • The role of the gut microbiome and probiotics in surgical outcomes is an emerging area of research.

Purpose Of The Study

  • To evaluate the impact of perioperative probiotic administration on patient prognosis following hepatectomy.
  • To synthesize evidence from randomized controlled trials (RCTs) regarding probiotic use in liver resection patients.

Main Methods

  • A comprehensive literature search was conducted across electronic databases for relevant RCTs.
  • Data extraction, risk of bias assessment, and meta-analysis were performed independently by two researchers.
  • RevMan 5.4 software was utilized for the statistical analysis of pooled data.

Main Results

  • The meta-analysis included 14 studies with 988 patients.
  • Probiotics significantly reduced postoperative infectious complications, serum endotoxin levels, white blood cell counts, and hospital stays.
  • No significant differences were observed in liver function indices (ALT, AST, TBiL, INR) or inflammatory markers (CRP, procalcitonin, IL-6).

Conclusions

  • Perioperative probiotics demonstrate a beneficial effect in reducing infection risk and shortening hospital stays for hepatectomy patients.
  • Probiotics do not appear to significantly aid in the restoration of liver function or the reduction of systemic inflammation after liver resection.

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