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Mosquito vector competence for Japanese encephalitis virus: a systematic review and meta-analysis update
Stephen Edache1, Andrea L Dixon2, Ana R S Oliveira3
1Department of Diagnostic Medicine and Pathobiology, Center for Outcomes Research and Epidemiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Parasites & Vectors
|May 26, 2025
Summary
Japanese encephalitis virus (JEV) is spreading, and this study updates vector competence for JEV in mosquitoes. Culicini mosquitoes show high infection and transmission rates, informing control strategies.
Area of Science:
- Medical Entomology
- Infectious Diseases
- Epidemiology
Background:
- Japanese encephalitis virus (JEV) is an emerging zoonotic disease transmitted by mosquitoes.
- JEV has recently expanded geographically into Mainland Australia.
- Research on JEV vector competence is increasing.
Purpose of the Study:
- To update a 2018 systematic review and meta-analysis on JEV vector competence.
- To quantitatively summarize data from scientific literature published between 2016 and 2023.
- To assess JEV vector competence in various mosquito species.
Main Methods:
- Systematic literature review of JEV vector and host competence (2016-2023).
- Searched PubMed, Scopus, Web of Science, and AFPMB databases.
- Utilized random-effects meta-analysis for effect sizes and meta-regression to identify associated variables.
Main Results:
- Included 74 new reports, identifying 9-12 additional competent mosquito species.
- Overall JEV infection, dissemination, and transmission rates were 45.4%, 41.2%, and 22.7%, respectively.
- Culicini mosquitoes exhibited the highest infection (51.9%) and transmission (27.8%) rates; mosquito subfamily/tribe was consistently associated with outcomes.
Conclusions:
- This study provides a quantitative update on JEV vector competence.
- Vector competence data are crucial for risk assessment and surveillance programs.
- Findings support the development of effective prevention and control strategies for JEV.
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