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Site- and Stage-Adapted Treatment Strategies for Gastrointestinal Diffuse Large B-Cell Lymphoma
Yu Yagi1, Yusuke Kanemasa1, Yuki Sasaki1
1Department of Medical Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Gastrointestinal diffuse large B-cell lymphoma (GI-DLBCL) survival is comparable to non-GI-DLBCL. Site- and stage-specific treatments may improve outcomes for GI-DLBCL patients.
Area of Science:
- Oncology
- Hematology
- Gastroenterology
Background:
- Gastrointestinal diffuse large B-cell lymphoma (GI-DLBCL) management is varied, with optimal treatment strategies debated.
- Understanding the prognostic factors and survival outcomes specific to GI-DLBCL is crucial for refining treatment approaches.
Purpose of the Study:
- To compare the survival outcomes of GI-DLBCL with non-GI-DLBCL.
- To analyze the impact of disease stage on survival in gastric and intestinal DLBCL.
- To evaluate treatment efficacy and associated risks in localized GI-DLBCL.
Main Methods:
- Retrospective analysis of 701 DLBCL patients (2004-2024), including 160 with GI-DLBCL.
- Comparison of baseline characteristics and survival between GI-DLBCL and non-GI-DLBCL cohorts.
- Subgroup analysis of gastric and intestinal DLBCL by disease stage.
Main Results:
- No significant difference in overall survival (OS) between GI-DLBCL and non-GI-DLBCL groups.
- Advanced disease in gastric and intestinal DLBCL was associated with poorer OS.
- Localized gastric DLBCL treated with chemoradiation had higher secondary cancer risk; localized intestinal DLBCL with surgery and chemotherapy showed favorable OS.
Conclusions:
- GI-DLBCL survival outcomes are comparable to non-GI-DLBCL.
- Site- and stage-specific therapeutic strategies are suggested to potentially enhance survival benefits in GI-DLBCL.
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