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Updated: Sep 20, 2025

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A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
Published on: November 12, 2020
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"Cilioretinal artery occlusion: Current scenario"
Ginu Pm1, Aiswarya R1, Sanjay Dhar1
1Department of Ophthalmology, Command Hospital Chandimandir, Panchkula, Haryana, India.
European Journal of Ophthalmology
|May 27, 2025
Summary
Cilioretinal artery occlusions (CLRAO) are rare, often unilateral events. Early intervention with thrombolytics or hyperbaric oxygen may improve outcomes for this vision-threatening condition.
Area of Science:
- Ophthalmology
- Vascular Medicine
- Retinal Imaging
Background:
- Cilioretinal artery occlusion (CLRAO) accounts for approximately 5% of retinal artery occlusions.
- It predominantly affects individuals unilaterally and is typically located temporally.
- Risk factors are diverse, including emboli, vasculitis, and hypercoagulable states.
Purpose of the Study:
- To review the etiopathogenesis, clinical presentation, imaging features, and management strategies for CLRAO.
- To highlight the association of CLRAO with conditions like central retinal vein occlusion, ischemic optic neuropathy, and paracentral acute middle maculopathy (PAMM).
- To discuss current and potential therapeutic interventions for CLRAO.
Main Methods:
- Review of existing literature on CLRAO.
- Analysis of clinical presentations and diagnostic imaging findings (FFA, SD OCT, OCTA).
- Evaluation of management options including thrombolysis, hyperbaric oxygen, and corticosteroids.
Main Results:
- CLRAO can present in isolation or with other vascular events.
- Imaging reveals characteristic findings like slow arterial filling and retinal layer hyperreflectivity.
- Paracentral scotomas are common, sometimes associated with PAMM.
Conclusions:
- CLRAO is a significant cause of vision loss with varied etiologies.
- Prompt diagnosis and timely intervention are crucial for visual prognosis.
- Further research and clinical trials are needed to optimize CLRAO management.

