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Related Experiment Video

Updated: Sep 20, 2025

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

Published on: November 12, 2020

"Cilioretinal artery occlusion: Current scenario".

Ginu Pm¹, Aiswarya R¹, Sanjay Dhar¹

¹Department of Ophthalmology, Command Hospital Chandimandir, Panchkula, Haryana, India.

European Journal of Ophthalmology

|May 27, 2025

Summary

This summary is machine-generated.

Cilioretinal artery occlusions (CLRAO) are rare, often unilateral events. Early intervention with thrombolytics or hyperbaric oxygen may improve outcomes for this vision-threatening condition.

Keywords:

Arterial occlusive disease < RETINA optic neuropathy < NEURO OPHTHALMOLOGY retinal cell biology < RETINA retinal degenerations associated with systemic disease < RETINA retinal pathology /Research < RETINA

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Area of Science:

Ophthalmology
Vascular Medicine
Retinal Imaging

Background:

Cilioretinal artery occlusion (CLRAO) accounts for approximately 5% of retinal artery occlusions.
It predominantly affects individuals unilaterally and is typically located temporally.
Risk factors are diverse, including emboli, vasculitis, and hypercoagulable states.

Purpose of the Study:

To review the etiopathogenesis, clinical presentation, imaging features, and management strategies for CLRAO.
To highlight the association of CLRAO with conditions like central retinal vein occlusion, ischemic optic neuropathy, and paracentral acute middle maculopathy (PAMM).
To discuss current and potential therapeutic interventions for CLRAO.

Main Methods:

Review of existing literature on CLRAO.
Analysis of clinical presentations and diagnostic imaging findings (FFA, SD OCT, OCTA).
Evaluation of management options including thrombolysis, hyperbaric oxygen, and corticosteroids.

Main Results:

CLRAO can present in isolation or with other vascular events.
Imaging reveals characteristic findings like slow arterial filling and retinal layer hyperreflectivity.
Paracentral scotomas are common, sometimes associated with PAMM.

Conclusions:

CLRAO is a significant cause of vision loss with varied etiologies.
Prompt diagnosis and timely intervention are crucial for visual prognosis.
Further research and clinical trials are needed to optimize CLRAO management.