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Breast Myofibroblastoma: A Single Institutional Case Series
Meghna Pinnaka1, Melissa Garcia Patino1, Vasupriya Ravi2,3
1Department of Pathology, UT Health San Antonio Long School of Medicine, San Antonio, Texas, USA.
European Journal of Breast Health
|May 27, 2025
Summary
Breast myofibroblastoma (BM) is a rare benign tumor. Surgical excision offers favorable outcomes, but distinguishing BM from other spindle cell tumors is crucial for accurate diagnosis and management.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Breast myofibroblastoma (BM) is an uncommon benign mesenchymal tumor.
- It predominantly affects older males and postmenopausal females.
Purpose of the Study:
- To analyze the clinicopathologic features of breast myofibroblastoma.
- To evaluate immunohistochemical profiles and treatment outcomes for BM.
Main Methods:
- Retrospective review of five BM cases diagnosed between 1998 and 2024.
- Analysis of clinical, histopathologic, and immunohistochemical data.
- Assessment of surgical treatment approaches and follow-up outcomes.
Main Results:
- Median age at diagnosis was 68 years; mean tumor size was 5.06 cm.
- Histopathology revealed spindle cells with adipose tissue and collagen.
- Immunohistochemistry showed positivity for desmin and CD34; S100 was negative.
Conclusions:
- Breast myofibroblastoma is a benign entity with excellent prognosis after surgical excision.
- Variability in immunohistochemical staining necessitates careful differentiation from other spindle cell tumors.
- Further case studies and refined diagnostic markers can improve clinical management.
