Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

526
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
526
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

66
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
66
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

59
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
59
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

849
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
849
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

660
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
660
Cardiac Catheterization IV: Nursing Management01:26

Cardiac Catheterization IV: Nursing Management

205
Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
205

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alterations of Cerebral Extracellular Vesicle microRNA Profiling Potentially Disrupts Brain Homeostasis Following Myocardial Infarction.

Biomolecules·2026
Same author

Rapid coronary artery stent computational simulation using the simplex deformable model.

Medical engineering & physics·2026
Same author

Cardiac Mitochondrial Dysfunction Following Bleomycin-Induced Acute Lung Injury in Rats.

bioRxiv : the preprint server for biology·2026
Same author

Sex-Specific Pathophysiological Signatures in Allometric Dosing-Controlled Bleomycin Acute Lung Injury Model.

bioRxiv : the preprint server for biology·2026
Same author

Lifetime Deletion of Skeletal Muscle Keap1 Attenuates Aging-Induced Cardiac Dysfunction via an Nrf2-Antioxidant Mechanism.

Antioxidants (Basel, Switzerland)·2025
Same author

Neural Inflammation in Thoracic Dorsal Root Ganglia Mediates Cardiopulmonary Spinal Afferent Sensitization in Chronic Heart Failure.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Sep 20, 2025

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.5K

Sympathetic Vasomotion Reflects Catheter-Based Radiofrequency Renal Denervation.

Peter Ricci Pellegrino1,2, Irving H Zucker3, Yiannis S Chatzizisis4

  • 1Department of Anesthesiology (P.R.P., H.-J.W.), University of Nebraska Medical Center, Omaha, NE.

Hypertension (Dallas, Tex. : 1979)
|May 27, 2025
PubMed
Summary

Renal sympathetic vasomotion, a new marker, can confirm effective renal denervation during procedures. This method helps improve the safety and consistency of radiofrequency renal denervation for hypertension treatment.

Keywords:
antihypertensive agentsarterial pressureautonomic denervationfeedbackkidneyregional blood flowsympathetic nervous system

More Related Videos

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

343
Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.
11:08

Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.

Published on: February 14, 2018

10.3K

Related Experiment Videos

Last Updated: Sep 20, 2025

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.5K
Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

343
Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.
11:08

Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.

Published on: February 14, 2018

10.3K

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Nephrology

Background:

  • Renal denervation efficacy is difficult to confirm due to challenges in assessing targeted renal sympathetic nerve ablation.
  • Autoregulatory mechanisms obscure the effects of renal denervation on mean renal blood flow.
  • Renal sympathetic vasomotion is proposed as a novel marker to evaluate the success of renal sympathetic nerve ablation.

Purpose of the Study:

  • To investigate if renal sympathetic vasomotion, a marker of rhythmic sympathetic control, reflects the effectiveness of successive radiofrequency renal denervation procedures.
  • To assess the utility of renal sympathetic vasomotion as an intraprocedural feedback tool for renal denervation.

Main Methods:

  • Unilateral surgical renal denervation was performed on 10 pigs.
  • Contralateral kidneys underwent four successive rounds of catheter-based radiofrequency renal denervation.
  • Bilateral renal blood flow velocity and abdominal aortic pressure were measured to calculate renal vasomotion before and after ablations.

Main Results:

  • Significant differences in renal vasomotion profiles were observed between innervated and surgically denervated kidneys prior to catheter denervation.
  • Ablation of the largest renal branch artery reduced renal sympathetic vasomotion by 52%.
  • Further ablation of remaining renal branches reduced sympathetic vasomotion by 95%, eliminating inter-kidney differences. Additional main renal artery denervation yielded no further consistent reduction.

Conclusions:

  • Renal sympathetic vasomotion serves as a viable marker for assessing the success of renal denervation.
  • This marker can provide real-time feedback during catheter-based renal denervation procedures.
  • Utilizing renal sympathetic vasomotion may enhance the efficacy, safety, and consistency of renal denervation for hypertension management.