Related Experiment Video

Updated: Sep 20, 2025

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

15.4K

Lipoprotein(a) and Coronary Calcification: Prognostic Implications in Rotational Atherectomy Patients

Yaolin Chen1,2,3, Wei Gao2,3,4, Yinman Wang1,2,3,4

  • 1Department of Cardiology, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, China.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|May 27, 2025
PubMed

Insights

Elevated Lipoprotein(a) [Lp(a)] levels (≥50 mg/dL) are linked to major adverse cardiac events (MACE) in patients undergoing rotational atherectomy. Markedly elevated Lp(a) (≥68.3 mg/dL) also predicts cardiovascular death, particularly in smokers and those with comorbidities.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Interventional Cardiology

Background:

  • Elevated Lipoprotein(a) [Lp(a)] is a known risk factor for major adverse cardiac events (MACE).
  • The prognostic role of Lp(a) in patients with severe coronary calcifications undergoing rotational atherectomy (RA) is not well-defined.
  • This study investigates the association between Lp(a) levels and clinical outcomes post-RA in this specific patient cohort.

Purpose of the Study:

  • To determine the prognostic value of Lipoprotein(a) [Lp(a)] in patients with severe coronary calcifications after rotational atherectomy (RA).
  • To assess the relationship between Lp(a) levels and the risk of major adverse cardiac events (MACE) and cardiovascular death (CVD).

Main Methods:

  • Retrospective analysis of data from 494 patients who underwent RA.
  • Stratification of Lp(a) levels into <50 mg/dL and ≥50 mg/dL categories.
  • Evaluation of MACE and CVD as primary outcomes, with survival analysis and Cox regression.

Main Results:

  • Patients with Lp(a) ≥50 mg/dL showed a significantly higher incidence of MACE (log-rank p=0.006).
  • An optimal threshold of 68.3 mg/dL for CVD was identified, with Lp(a) ≥68.3 mg/dL associated with increased CVD risk (log-rank p=0.02).
  • Lp(a) was an independent risk factor for MACE, especially in smokers and patients with comorbidities.

Conclusions:

  • Lp(a) ≥50 mg/dL is independently associated with MACE in patients with severe coronary calcification undergoing RA.
  • Markedly elevated Lp(a) levels (≥68.3 mg/dL) are associated with cardiovascular death.
  • Lp(a) identifies a higher MACE risk subgroup, including smokers and those with comorbidities.
Abstract

Keywords:
CVDLp(a)MACEcoronary calcification

More Related Videos

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.1K
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
130
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
44
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
40
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
69
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
42
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
97