Poxvirus pathology and pathogenesis in agriculturally important species

Amy L MacNeill1, Juan Francisco Micheloud2,3,4, Rokshana Parvin5

  • 1Colorado State University, Fort Collins, CO.

PubMed

Insights

Poxviruses, like monkeypox virus (MPV), affect many animal species. This review details poxvirus pathology and pathogenesis in agriculturally important animals, aiding in understanding and managing disease outbreaks.

Area of Science:

  • Veterinary Pathology
  • Virology
  • Comparative Pathology

Background:

  • Zoonotic poxviruses, including monkeypox virus (MPV), are gaining attention due to global outbreaks.
  • Discontinuation of smallpox vaccination has increased susceptibility to orthopoxviruses.
  • Poxviridae infect a wide range of vertebrate and invertebrate species.

Purpose of the Study:

  • To review the pathology and pathogenesis of poxviruses.
  • Focus on species of agricultural significance.

Main Methods:

  • Literature review of poxvirus infections.
  • Analysis of clinical signs and histologic lesions.
  • Comparative analysis across different animal species.

Main Results:

  • Poxviral infections exhibit diverse clinical signs and lesions.
  • Species-specific variations in poxvirus pathology exist.
  • Understanding pathogenesis is crucial for disease management.

Conclusions:

  • Poxviruses pose a significant threat to agricultural animal health.
  • Further research into species-specific poxvirus interactions is warranted.
  • Effective disease surveillance and control strategies are essential.