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Updated: May 9, 2026

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
Published on: April 28, 2015
Design of colloidal vectors for active targeting via complexation of biotinylated copolymers with gadolinium ions
Maksym Odnoroh1, Franck Desmoulin2,3, Olivier Coutelier1
1Université de Toulouse, CNRS UMR 5623, Laboratoire Softmat, Toulouse, France. mathias.destarac@univ-tlse3.fr.
Abstract:
This study presents the design of biotin-functionalized hybrid polyionic complexes (HPICs) using RAFT polymers for MRI applications. The synthesized colloidal vectors, complexed with gadolinium ions, demonstrate high stability, relaxivity, and biotin accessibility for active targeting. Preliminary in vivo studies confirm their potential for improved MRI contrast and pharmacokinetic tracking.
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