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[Morphologic analysis of the thymo-lymphatic status in neonates and in early childhood]
Insights
This study examined thymolymphatic state in 31 children, revealing distinct immune and adrenal responses in secondary versus idiopathic cases. These immune insufficiencies and adrenal atrophy may contribute to mortality in affected infants.
Area of Science:
- Pediatric Pathology
- Immunology
- Endocrinology
Abstract:
Lesions of B- and T-systems as well as of suprarenal cortex were studied in a group of 31 children (at the age of 2 days till 3.5 years) suffering from thymolymphatic state and correlated with their basic disease. 25 cases were of a secondary type, 6 cases belonged to an idiopathic (primary) type. Secondary thymolymphatic state mostly occurred with inflammatory diseases of the respiratory system and was characterized by a B-system exhaustion, T-system activation and suprarenal atrophy. Idiopathic thymolymphatic state found in sudden and unexpected deaths was combined with variegated B-reactin and T-system activation. Insufficiency of immune reactions (morphological as well as functional) and suprarenal cortical atrophy could contribute to the cause of death.