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Updated: Sep 20, 2025
Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice
Published on: February 10, 2023
Single anastomosis sleeve jejunal (SAS-J) bypass vs single anastomosis sleeve ileal (SASI) bypass, prospective
Alaa Mostafa Sewefy1, Mohamed A Abdelzaher2, Karim Sabry3
1Department of Surgery, Minia University, Minya, Egypt.
Background:
Single anastomosis sleeve ileal (SASI) bypass is a modification of Santoro's operation. Which aimed to keep normal food pathway and allow endoscopic examination. The procedure was modified to single anastomosis sleeve jejunal (SAS-J) bypass to minimize the nutritional deficiency. The study aimed to compare SASI to SAS-J bypass.
Materials And Methods:
This was a prospective randomized controlled trial that included 180 patients. Patients were randomly assigned to two equal groups: Group 1, was operated with SASI bypass while Group 2 was operated with SAS-J bypass. All patients complete at least 1 year of follow-up.
Results:
A total of 63% of patients were female and 37% were male. The mean body mass index was 47.6. The mean age was 36 years. The total incidence of malnutrition was 58% in Group 1 vs 27.6% in Group 2 ( P = 0.000). Protein malnutrition occurred in 15.9% of Group 1 vs 4.6% in Group 2 ( P = 0.014). Anemia occurred in 14.8% in Group 1 vs 5.7% in Group 2 ( P = 0.049). %EWL at 1 year was 94.8 in Group 1 vs 90.6 in Group 2 ( P = 0.005). Diarrhea occurred in 21.6% in Group 1 vs 8% in Group 2 ( P = 0.012). The incidence of excessive weight loss was 11.4% in Group 1 vs 2.3% in Group 2 ( P = 0.0031). The rate of reoperation was 11.4% in Group 1 vs 2.3% in Group 2 ( P = 0.018).
Conclusions:
Both SASI and SAS-J bypass are effective as a metabolic and a weight loss surgery, but, SAS-J bypass is associated with less nutritional deficiency and less complications rate compared to SASI bypass.
