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Related Concept Videos

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Characterizing Plasma-Based Metabolomic Signatures for Metastasis in Non-Small Cell Lung Cancer.

Manlu Liu1, Yanlong Zhu2,3, Sean J McIlwain4

  • 1Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53726, USA.

Metabolites
|May 27, 2025
PubMed
Summary

Researchers identified a unique metabolomic signature in non-small cell lung cancer (NSCLC) patients that predicts early metastasis after radiation therapy. This discovery offers a new way to assess metastatic risk in NSCLC.

Keywords:
biomarkersclinical studylung cancermetabolomics

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Area of Science:

  • Oncology
  • Metabolomics
  • Mass Spectrometry

Background:

  • Conventional imaging for non-small cell lung cancer (NSCLC) staging has limitations in detecting micrometastatic disease.
  • Functional assessment of NSCLC progression may offer insights into metastatic risk prediction.

Purpose of the Study:

  • To identify a metabolomic signature predictive of metastasis in NSCLC patients undergoing definitive radiation therapy.

Main Methods:

  • Prospective plasma sample collection from NSCLC patients treated with definitive radiation.
  • Metabolite analysis using flow injection electrospray-Fourier transform ion cyclotron resonance mass spectrometry (FIE-FTICR-MS).
  • Definition of early metastasis as occurrence within 1 year of radiation treatment.

Main Results:

  • 51 metabolic features, including glycerophospholipids, sphingolipids, and fatty acyls, differed between patients with and without early metastasis (adjusted p < 0.05).
  • In follow-up samples, 174 metabolic features were significantly altered in patients who developed early metastasis.
  • FIE-FTICR-MS demonstrated high reproducibility in technical replicates.

Conclusions:

  • Distinct metabolic profile changes were observed in NSCLC patients who developed metastasis within one year of radiation.
  • Metabolomic profiling shows potential as a predictive tool for assessing metastatic risk in NSCLC.