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Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings
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Mini-review: Insight of bacteriophage therapy in clinical practice
Smita Ghosh1, Shrabani Pradhan2, Kuntal Ghosh3
1Department of Biological Sciences, Midnapore City College, Midnapore, West Bengal, India; Biodiversity and Environmental Studies Research Center, Midnapore City College Affiliated to Vidyasagar University, Midnapore, West Bengal, India.
Virology
|May 27, 2025
Summary
Bacteriophage therapy offers a promising alternative to antibiotics for treating drug-resistant infections. This approach leverages bacteriophages (phages) for their specificity and potential to overcome antibiotic resistance, despite existing challenges.
Area of Science:
- Microbiology
- Biotechnology
- Infectious Diseases
Background:
- Antibiotic resistance necessitates alternative therapeutic strategies.
- Bacteriophage therapy presents a viable alternative to conventional antibiotics.
- Phage therapy offers advantages like specificity, auto-dosing, and biofilm penetration.
Purpose of the Study:
- To review the therapeutic potential of bacteriophage therapy.
- To explore phage mechanisms within mammalian immune systems.
- To discuss advancements in phage engineering and regulatory aspects.
Main Methods:
- Compilation of research on phage therapy mechanisms.
- Review of therapeutic applications and challenges.
- Analysis of phage engineering and immune system interactions.
Main Results:
- Phage therapy demonstrates high specificity and potential against multidrug-resistant bacteria.
- Phage-derived enzymes and engineered phages enhance therapeutic efficacy.
- Overcoming regulatory and manufacturing hurdles is crucial for widespread adoption.
Conclusions:
- Bacteriophage therapy is a hopeful alternative to antibiotics for multidrug-resistant infections.
- Further research into phage engineering and immune interactions will advance clinical applications.
- Phages are poised to become a key medical treatment for bacterial infections.
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