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Updated: Jun 14, 2025
A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Short-term prognostic value of cranial volume in patients with cerebral hemorrhage based on propensity score matching
Jianda Sun1, Hongli Zhang1, Shouyue Wu1
1Department of Neurosurgery, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, PR China; Heilongjiang Province Neuroscience Institute, Harbin, Heilongjiang Province 150001, PR China.
Objectives:
The purpose of this study was to investigate whether cranial volume can improve the accuracy of prognosis, and to explore the relationship between the prognosis of patients with cerebral hemorrhage and the cranial volume and anterior and posterior diameter.
Methods:
We obtained data from patients diagnosed with spontaneous cerebral hemorrhage between 2018 and 2020 at the First Hospital of Harbin Medical University. The hematoma volume to cranial volume ratio (HVCVR) was calculated as the ratio of hematoma volume to cranial volume. Multivariate logistic regression models were developed to assess the predictive power of hematoma volume and HVCVR. Propensity score matching was employed to adjust for baseline differences in cranial volume. Multiple logistic regression models were used to explore the relationship between cranial diameter and prognosis.
Results:
Among 3494 patients, 1,796 (51.4%) had poor outcomes. Poor outcomes were associated with larger HVCVR values, and multivariate analysis confirmed HVCVR as an independent predictor (OR 1.722, 95 % CI 1.471-2.206, P < 0.001), outperforming hematoma volume alone (AUC 0.774 vs. 0.761, P < 0.001). Propensity-matched cohorts (n = 1199 each) revealed that larger intracranial volume correlated with better prognosis (OR 0.802, 95 % CI 0.683-0.942, P = 0.002).
Conclusion:
Our study suggests that HVCVR provides a more accurate prediction of prognosis in spontaneous cerebral hemorrhage patients. Greater cranial volume and a more flattened cranial cavity may potentially influence positive prognoses in patients with cerebral hemorrhage.
