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Updated: Sep 20, 2025
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Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
Published on: October 9, 2014
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Alternative Splicing Regulation in Metabolic Disorders.
1Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Summary
Alternative splicing (AS) regulates gene expression and is vital for metabolic health. Dysregulation of AS contributes to metabolic disorders, offering potential therapeutic targets.
Area of Science:
- Molecular Biology
- Genetics
- Metabolomics
Background:
- Alternative splicing (AS) enhances transcriptome diversity and regulates gene expression.
- AS plays a crucial role in cellular processes and the development of complex traits.
Purpose of the Study:
- To review the role of AS in metabolic disorders like obesity and metabolic syndrome.
- To explore molecular mechanisms, genetic influences, and clinical relevance of AS in metabolic diseases.
Main Methods:
- Review of literature on alternative splicing mechanisms and regulation.
- Analysis of high-throughput sequencing and bioinformatics data on AS events.
- Examination of genetic variants, including splicing quantitative trait loci (sQTLs).
Main Results:
- AS is extensively involved in metabolic regulation across various tissues.
- Genetic variants and epigenetic modifications (e.g., m6A) significantly impact AS.
- Splicing misregulation is linked to metabolic diseases, with therapeutic potential.
Conclusions:
- Alternative splicing is a critical factor in metabolic health and disease.
- Understanding AS mechanisms and regulation is key for developing novel therapies for metabolic disorders.
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