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Updated: Feb 12, 2026
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Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
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Development of Hydroxyapatite as a Bone Implant Biomaterial for Triggering Osteogenesis
Yusuf Alif Pratama1, Honey Dzikri Marhaeny1, Fani Deapsari1
1Doctoral Program of Pharmaceutical Science, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
European Journal of Dentistry
|May 27, 2025
Summary
Bone defects are rising, necessitating effective biomaterials for bone grafting. Hydroxyapatite shows promise due to its biocompatibility and ability to promote bone healing and osteogenesis.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Regenerative Medicine
Background:
- Bone defects are increasing globally, driven by population density and activity levels.
- Bone grafting using biomaterials is a key surgical approach for bone replacement and healing.
- Effective biomaterials must possess biocompatibility, osteoconductivity, and osteoinductivity to promote osteogenesis.
Purpose of the Study:
- To identify biomaterials with favorable properties for bone regeneration.
- To evaluate hydroxyapatite's characteristics and their role in inducing osteogenesis.
Main Methods:
- Comprehensive literature review of publications on bone ossification.
- Analysis of factors influencing bone healing processes.
- Evaluation of hydroxyapatite's physicochemical properties relevant to osteogenesis.
Main Results:
- Specific hydroxyapatite characteristics, including a phosphate/calcium ratio near 1.67, porosity (40-60%), pore diameter (200-900 nm), and crystallinity (40-60%), are crucial for effective osteogenesis.
- Hydroxyapatite demonstrates significant osteoconductive, osteoinductive, and osteointegrative properties.
Conclusions:
- Hydroxyapatite is a highly suitable biomaterial for bone grafting applications.
- Optimized hydroxyapatite properties can significantly enhance bone regeneration and healing outcomes.
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