Related Experiment Video

Updated: Jan 18, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.4K

Serum matrix metalloproteinase-9 as a predictor of recurrence in idiopathic nephrotic syndrome

Masahiko Ochi1, Akinori Hara2,3, Shiori Nakagawa1

  • 1Department of Nephrology and Rheumatology, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.

Clinical and Experimental Nephrology
|May 27, 2025
PubMed
Abstract

Insights

Higher serum matrix metalloproteinase-9 (MMP-9) levels during nephrotic syndrome predict recurrence risk in patients with idiopathic nephrotic syndrome (INS). This finding suggests MMP-9 may serve as a valuable predictive marker for INS relapse.

Area of Science:

  • Nephrology
  • Biochemistry
  • Clinical Medicine

Background:

  • Idiopathic nephrotic syndrome (INS) recurrence risk factors are largely unknown.
  • Previous research suggests a link between matrix metalloproteinase-9 (MMP-9) and proteinuria in INS.
  • This study investigates serum MMP-9 levels as a predictor of INS recurrence.

Purpose of the Study:

  • To determine if baseline serum MMP-9 levels correlate with the risk of subsequent recurrence in patients with INS.
  • To explore MMP-9 as a potential biomarker for predicting INS relapse.

Main Methods:

  • Retrospective analysis of 29 biopsy-proven INS patients (1998-2016).
  • Serum MMP-9 levels measured via ELISA during the nephrotic phase.
  • Recurrence defined by urinary protein levels exceeding 2+ or 1 g/g creatinine.

Main Results:

  • 12 out of 29 patients (41.4%) experienced recurrence over a median follow-up of 130 days.
  • Recurrent patients were younger, had higher eGFR, and higher baseline serum MMP-9 levels.
  • Elevated baseline serum MMP-9 significantly increased the risk of subsequent recurrence (HR: 5.687).

Conclusions:

  • Baseline serum MMP-9 levels during the nephrotic phase are associated with subsequent INS recurrence.
  • Serum MMP-9 shows potential as a predictive marker for future recurrence in INS patients.
Keywords:
BiomarkerFocal segmental glomerulosclerosisMatrix metalloproteinase-9Minimal change diseaseRecurrence

More Related Videos

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

8.8K
Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics10:50

Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics

Published on: July 16, 2018

16.9K

Related Concept Videos

Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
205
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
283
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
510
Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
3.3K
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
368