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Gut microbiota and relevant metabolites analysis in perianal abscess of infants

Shuai Wang1, Jingfeng Zhang1, Mingfeng Fan1

  • 1Department of Anorectal Surgery, Affiliated Hospital of Jining Medical University, Jining, 272029, China.

BMC Microbiology
|May 27, 2025
PubMed

Insights

Infants with perianal abscess show distinct gut microbiota and metabolite profiles compared to healthy infants. This suggests a link between gut bacteria and infantile perianal abscess, aiding treatment strategies.

Area of Science:

  • Microbiology
  • Metabolomics
  • Pediatric Health

Background:

  • Infantile perianal abscess is a common condition in infants.
  • Understanding the underlying factors, including gut microbiota and metabolites, is crucial for effective treatment.

Purpose of the Study:

  • To investigate differences in gut microbiota and metabolite profiles between infants with perianal abscess and healthy controls.
  • To identify potential microbial and metabolic biomarkers associated with infantile perianal abscess.

Main Methods:

  • 16S rRNA gene sequencing was used to analyze gut microbiota composition in 19 infants with perianal abscess and 21 healthy infants.
  • Metabolite composition was analyzed in a subset of 16 infants with perianal abscess and 8 healthy infants.

Main Results:

  • Significant differences were observed in the abundance of Ruminococcus and Parasutterella genera between the groups.
  • Five metabolic pathways, including steroid biosynthesis and cholesterol metabolism, were significantly enriched.
  • Three metabolites—calcidiol, dihydrofolic acid, and taurochenodesoxycholic acid—were identified within these pathways.

Conclusions:

  • The gut microbiota and metabolite composition differ significantly between infants with and without perianal abscess.
  • These findings suggest a potential association between gut microbiota alterations and the development of infantile perianal abscess.
Abstract

Keywords:
Gut microbiotaInfantMetabolitesPerianal abscess

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