Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pancreas01:19

Pancreas

2.2K
The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
2.2K
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

349
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
349

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Liver transplantation in patients over 70 years old.

Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery·2025
Same author

Pancreas retransplantation.

Current opinion in organ transplantation·2025
Same author

Characteristics of Overlap Syndrome in a Large Cohort of Brazilian Patients With Systemic Sclerosis: A Retrospective Analysis.

The Journal of rheumatology·2025
Same author

LIVING DONOR LIVER TRANSPLANT FOR INTRAHEPATIC CHOLANGIOCARCINOMA. AN INITIAL BRAZILIAN EXPERIENCE.

Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery·2024
Same author

Banff 2022 pancreas transplantation multidisciplinary report: Refinement of guidelines for T cell-mediated rejection, antibody-mediated rejection and islet pathology. Assessment of duodenal cuff biopsies and noninvasive diagnostic methods.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2023
Same author

Understanding the Elevated Lethality of COVID-19 in Liver Transplant Recipients: Does Immunosuppression Management Matter? Results from a Brazilian Multicentric Historical Cohort.

Transplantation proceedings·2023
Same journal

Hepatic Congestion-linked Intrahepatic Biliary Strictures After Living Donor Liver Transplantation.

Transplantation·2026
Same journal

Filtered or Fried? Rethinking Intraoperative Cell Salvage in Liver Transplantation.

Transplantation·2026
Same journal

Simultaneous Liver-kidney Versus Liver Transplantation Categorized by Pretransplant eGFR: Impact of the 2017 OPTN Policy.

Transplantation·2026
Same journal

Preformed Anti-DQ Alpha Donor-specific Antibodies and the Risk of Antibody-mediated Rejection After Kidney Transplantation.

Transplantation·2026
Same journal

People in Transplantation: Professor Nadey Hakim, MD, PhD, FRCS, FRCSGlas (Hon), FACS, President-Elect of The Transplantation Society.

Transplantation·2026
Same journal

IL-1 Receptor Blockade Modulates Inflammation During Sequential Perfusion in Ex Vivo Porcine Kidneys.

Transplantation·2026
See all related articles

Related Experiment Video

Updated: Jan 18, 2026

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
10:43

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Published on: October 31, 2007

28.8K

Over 1000 Pancreas Transplants in a Latin American Program.

Marcelo Perosa1, Juan R Branez1, Fernanda R Danziere1

  • 1Pancreas and Kidney Transplant Program, Leforte Hospital, São Paulo, Brazil.

Transplantation
|May 28, 2025
PubMed
Summary
This summary is machine-generated.

Pancreas transplantation (PT) is a vital treatment for type 1 diabetes. This study shows a high-volume Brazilian program achieved excellent patient survival and reduced complications over 25 years.

More Related Videos

Surgical Tips and Tricks for Performing Porcine Pancreas Transplantation
10:32

Surgical Tips and Tricks for Performing Porcine Pancreas Transplantation

Published on: July 20, 2022

2.5K
Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation
09:01

Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation

Published on: July 27, 2022

2.5K

Related Experiment Videos

Last Updated: Jan 18, 2026

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
10:43

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Published on: October 31, 2007

28.8K
Surgical Tips and Tricks for Performing Porcine Pancreas Transplantation
10:32

Surgical Tips and Tricks for Performing Porcine Pancreas Transplantation

Published on: July 20, 2022

2.5K
Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation
09:01

Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation

Published on: July 27, 2022

2.5K

Area of Science:

  • Nephrology and Endocrinology
  • Transplant Surgery
  • Immunology

Background:

  • Pancreas transplantation (PT) effectively treats type 1 diabetes with end-stage renal disease or brittle diabetes.
  • Global PT volume and high-volume programs have declined recently.
  • This study analyzes 25 years of experience from a high-volume Brazilian PT program.

Purpose of the Study:

  • To analyze the outcomes of over 1000 pancreas transplants performed between 1996 and 2021.
  • To evaluate the evolution of surgical techniques and immunosuppression protocols.
  • To assess patient and graft survival rates in a high-volume setting.

Main Methods:

  • Retrospective analysis of 1073 PTs: 593 simultaneous pancreas-kidney (SPK) and 480 solitary PTs (331 PAK, 149 PTA).
  • Transplants categorized into three eras based on surgical techniques (systemic-bladder to portal-enteric, portal-duodenal, systemic-enteric).
  • Standard immunosuppression: thymoglobulin, tacrolimus, mycophenolate mofetil/sodium, and steroids.

Main Results:

  • Overall 1-year patient survival exceeded 90% for primary PTA/PAK and 85% for SPK/PRT.
  • 1-year death-censored graft survival was 97% (SPK-kidney), 90% (SPK-pancreas), and 75% (solitary PTs).
  • Significant reductions in cold ischemia time and pancreatic thrombosis (down to 2% in SPK) were observed over time.

Conclusions:

  • The Brazilian PT program maintained high-volume activity for 25 years.
  • The program has become one of the world's most active, performing over 60 PTs annually.
  • Surgical technique evolution and optimized protocols contributed to improved outcomes.